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The combination of NADH and ubiquinol provides antioxidant protection and sparks energy production at the cellular level.

Low energy? The real causes of fatigue usually lay deep within the cells-- in the energy-generation department. NADH and Ubiquinol are a synergistic combination of activated co-enzymes vital to energy production in the brain and body.

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About NADH + Ubiquinol

Ubiquinol is the biologically active form of coenzyme Q10. Ubiquinol is essential for the health of practically all tissues and organs because of its role in the production of energy in each cell. It also protects fats from oxidative damage. The organs that work biochemically the hardest for us-- the heart, the kidneys, and the liver--- contain the highest concentrations of ubiquinol.

Deficiency in CoEnzyme Q10 has been noted in many chronic disease conditions, especially cardiovascular and neurodegenerative diseases. Individuals using a statin drug for cholesterol reduction typically develop a drug-induced CoQ10 deficiency. Their production of CoQ10 is reduced and blocked by these medications, so they’re good candidates for supplementation.

NADH (nicotinamide adenine dinucleotide) is the main nutrient vital to creating cellular energy. It’s the activated co-enzyme form of NAD+, made in our bodies from vitamin B3 (niacin).

NADH functions like a spark plug for cellular energy production. Without NADH, the basic energy source for all cells could not be created. This energy—ATP—is created by the mitochondria: the tiny but mighty power-plants found in each cell.

Since the highest concentrations of NADH are ordinarily found in the brain, this suggests that NADH is most important to the brain’s energy supply. Think about this: each neuron—or brain cell—contains over 2 million mitochondria. NADH is the precursor to ATP, making it of great importance to our cognitive function. It’s no wonder lower levels of NADH are associated with decreased energy, mental fatigue, and brain fog. These symptoms are common experiences of those with established Parkinson’s disease, Fibromyalgia, Chronic Fatigue Syndrome, Long-COVID Syndrome and Alzheimer’s disease.

Even if you aren’t dealing with a diagnosed health condition, supplementing NADH becomes a good idea the older we get. That’s because as we age, our mitochondria can become less efficient and aren’t replaced at the same rate as when we were younger. This means lower NADH levels, lower ATP production, and lower ENERGY levels.

So when stress, advanced age and/or medical diagnoses are present, it makes sense to offer safe and effective supplementary NADH where backed by clinical application.



Asadi-Pooya AA, Akbari A, Emami A, et al. Long COVID syndrome-associated brain fog[published online ahead of print, 2021 Oct 21]. J Med Virol. 2021;10.

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Birkmayer GD. Stabilized NADH improves the physical and mental performance in highly conditioned athletes. Proceedings from the First International Conference on the Mechanism of Action of Nutraceuticals, Dubrovnik, Croatia, October 2001.

Birkmayer GJ, Birkmayer W. Stimulation of endogenous L-dopa biosynthesis--a new principle for the therapy of Parkinson's disease. The clinical effect of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotidephosphate (NADPH). Acta Neurol Scand Suppl. 1989;126:183-7.

Castro-Marrero, Jesus et al. Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trialClinical Nutrition 35:4;Aug.2016, 826-834.

Kaneka Nutrients. “Kaneka Ubiquinol.” Accessed online April 19, 2023.

Kirsch M, De Groot H. NAD(P)H, a directly operating antioxidant? FASEB J. 2001 Jul;15(9):1569-74.

Mayo Clinic. “CoEnzyme Q10”. Accessed online on Apr 26, 2023.

Nicolson GL, Settineri R, Ellithorpe R. Lipid replacement therapy with a glycophospholipid formulation with NADH and CoQ10 significantly reduces fatigue in intractable chronic fatiguing illnesses and chronic Lyme disease patients. Int J Clin Med. 2012;3(3):163–170.

Vrecko K, Storga D, Birkmayer JG, Möller R, Tafeit E, Horejsi R, Reibnegger G. NADH stimulates endogenous dopamine biosynthesis by enhancing the recycling of tetrahydrobiopterin in rat phaeochromocytoma cells. Biochim Biophys Acta. 1997 Jul 10;1361(1):59-65.

Xie, N., Zhang, L., Gao, W. et al. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Sig Transduct Target Ther 5, 227 (2020).

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