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DIM

Healthy Hormone Balance

DIM is an antioxidant compound derived from indole-3-carbinol ( I-3-C), a plant compound found in broccoli, kale, cauliflower, bok choy and other cruciferous vegetables.

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About DIM

DIM is an antioxidant compound derived from indole-3-carbinol ( I-3-C), a plant compound found in broccoli, kale, cauliflower, bok choy and other cruciferous vegetables.  

DIM is recognized for its role in promoting healthy estrogen balance in males and females by supporting the clearance of estrogen by the liver’s blood cleansing/detoxification processes.  DIM promotes the metabolic transformation of free estrogen and may reduce estrogen-mimicking substances (for ex. parabens, phthalates etc.) into weaker-acting estrogen metabolites, thereby decreasing their potential to affect estrogen-sensitive tissues in unwanted ways.  Its powerful antioxidant benefits help the body detoxify free radicals and enhances phase II detoxification processes in the liver, protecting cells from damage.  

Both females and males can benefit from taking DIM.

Females with estrogen-dominant conditions, such as premenstrual syndrome, cyclical mastalgia (fibrocystic breast disease), heavy menstrual periods, endometriosis, uterine fibroids, polycystic ovarian syndrome and associated acne, infertility problems, as well as peri-menopausal symptoms like hot flashes and mood swings can benefit from taking DIM daily.

Since DIM supports a healthy estrogen-to-testosterone ratio in males, those who are who are overweight with excess body fat, unwanted breast development, hormonal acne or prostate issues can also benefit from taking DIM.

Pure Lab’s DIM is fully activated and ready to provide hormone-balancing and antioxidant benefits to the body.  It’s contained within a special acid-resistant capsule designed to protect the DIM against the harsh conditions of the upper GI tract, providing superior bioavailability.  Plus, Pure Lab’s DIM provides antioxidant protection and hormone balancing without the uncomfortable GI effects produced by eating broccoli, cabbage and kale. 

Each capsule of Pure Lab’s DIM contains 200 milligrams of DIM in an acid-resistant preparation. Individuals can take 1 capsule daily, 30 minutes before a meal to support healthy hormone balance.

Ingredients

Research

Chang YC, Riby J, Chang GH, Peng BC, Firestone G, Bjeldanes LF. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, a major in vivo product of dietary indole-3-carbinol. Biochem Pharmacol. 1999;58(5):825-834.

Herraiz T, Galisteo J. Endogenous and dietary indoles: a class of antioxidants and radical scavengers in the ABTS assayFree Radic Res. 2004;38(3):323-331.

Higdon JV, Delage B, Williams DE, Dashwood RH. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res. 2007;55(3):224-236.

Laidlaw M, Cockerline CA, Sepkovic DW. Effects of a breast-health herbal formula supplement on estrogen metabolism in pre- and post-menopausal women not taking hormonal contraceptives or supplements: a randomized controlled trial [published correction appears in Breast Cancer (Auckl). 2012;6:1 Breast Cancer (Auckl). 2010;4:85-95. Published 2010 Dec 16.

Michnovicz JJ, Adlercreutz H, Bradlow HL. Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humansJ Natl Cancer Inst. 1997;89(10):718-723.

Michnovicz JJ. Increased estrogen 2-hydroxylation in obese women using oral indole-3-carbinol. Int J Obes Relat Metab Disord. 1998;22(3):227-229.

PubChem. Indole-3-carbinol. https://pubchem.ncbi.nlm.nih.gov/compound/3712

PubChem. 3,3’-Diindolylmethane. https://pubchem.ncbi.nlm.nih.gov/compound/3071

Reed GA, Arneson DW, Putnam WC, et al. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. Cancer Epidemiol Biomarkers Prev. 2006;15(12):2477-2481.

Reed GA, Sunega JM, Sullivan DK, Gray JC, Mayo MS, Crowell JA, Hurwitz A. Single -Dose Pharmacokinetics and Tolerability of Absorption-Enhanced 3,3’-Diindolylmethane in Healthy Subjects. Cancer Epidemiology, Biomarkers and Prevention 2008;17(10):2619 -2624.

Sarkar FH, Li Y. Indole-3-carbinol and prostate cancerJ Nutr. 2004;134(12 Suppl):3493S-3498S.

Thomson CA, Chow HHS, Wertheim BC, et al. A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Res Treat. 2017;165(1):97-107.

Yang X, Zheng X, Zhang M, Huang J, Huang P, Wang J. Drug-Induced Gynecomastia: Data Mining and Analysis of the FDA Adverse Event Reporting System Database. Clin Epidemiol. 2024;16:617-630. Published 2024 Sep 11.

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