DIM is an antioxidant compound derived from indole-3-carbinol ( I-3-C), a plant compound found in broccoli, kale, cauliflower, bok choy and other cruciferous vegetables.
DIM is recognized for its role in promoting healthy estrogen balance in males and females by supporting the clearance of estrogen by the liver’s blood cleansing/detoxification processes. DIM promotes the metabolic transformation of free estrogen and may reduce estrogen-mimicking substances (for ex. parabens, phthalates etc.) into weaker-acting estrogen metabolites, thereby decreasing their potential to affect estrogen-sensitive tissues in unwanted ways. Its powerful antioxidant benefits help the body detoxify free radicals and enhances phase II detoxification processes in the liver, protecting cells from damage.
Both females and males can benefit from taking DIM.
Females with estrogen-dominant conditions, such as premenstrual syndrome, cyclical mastalgia (fibrocystic breast disease), heavy menstrual periods, endometriosis, uterine fibroids, polycystic ovarian syndrome and associated acne, infertility problems, as well as peri-menopausal symptoms like hot flashes and mood swings can benefit from taking DIM daily.
Since DIM supports a healthy estrogen-to-testosterone ratio in males, those who are who are overweight with excess body fat, unwanted breast development, hormonal acne or prostate issues can also benefit from taking DIM.
Pure Lab’s DIM is fully activated and ready to provide hormone-balancing and antioxidant benefits to the body. It’s contained within a special acid-resistant capsule designed to protect the DIM against the harsh conditions of the upper GI tract, providing superior bioavailability. Plus, Pure Lab’s DIM provides antioxidant protection and hormone balancing without the uncomfortable GI effects produced by eating broccoli, cabbage and kale.
Each capsule of Pure Lab’s DIM contains 200 milligrams of DIM in an acid-resistant preparation. Individuals can take 1 capsule daily, 30 minutes before a meal to support healthy hormone balance.
Chang YC, Riby J, Chang GH, Peng BC, Firestone G, Bjeldanes LF. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, a major in vivo product of dietary indole-3-carbinol. Biochem Pharmacol. 1999;58(5):825-834.
Herraiz T, Galisteo J. Endogenous and dietary indoles: a class of antioxidants and radical scavengers in the ABTS assay. Free Radic Res. 2004;38(3):323-331.
Higdon JV, Delage B, Williams DE, Dashwood RH. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res. 2007;55(3):224-236.
Laidlaw M, Cockerline CA, Sepkovic DW. Effects of a breast-health herbal formula supplement on estrogen metabolism in pre- and post-menopausal women not taking hormonal contraceptives or supplements: a randomized controlled trial [published correction appears in Breast Cancer (Auckl). 2012;6:1 Breast Cancer (Auckl). 2010;4:85-95. Published 2010 Dec 16.
Michnovicz JJ, Adlercreutz H, Bradlow HL. Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans. J Natl Cancer Inst. 1997;89(10):718-723.
Michnovicz JJ. Increased estrogen 2-hydroxylation in obese women using oral indole-3-carbinol. Int J Obes Relat Metab Disord. 1998;22(3):227-229.
PubChem. Indole-3-carbinol. https://pubchem.ncbi.nlm.nih.gov/compound/3712
PubChem. 3,3’-Diindolylmethane. https://pubchem.ncbi.nlm.nih.gov/compound/3071
Reed GA, Arneson DW, Putnam WC, et al. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane. Cancer Epidemiol Biomarkers Prev. 2006;15(12):2477-2481.
Reed GA, Sunega JM, Sullivan DK, Gray JC, Mayo MS, Crowell JA, Hurwitz A. Single -Dose Pharmacokinetics and Tolerability of Absorption-Enhanced 3,3’-Diindolylmethane in Healthy Subjects. Cancer Epidemiology, Biomarkers and Prevention 2008;17(10):2619 -2624.
Sarkar FH, Li Y. Indole-3-carbinol and prostate cancer. J Nutr. 2004;134(12 Suppl):3493S-3498S.
Thomson CA, Chow HHS, Wertheim BC, et al. A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Res Treat. 2017;165(1):97-107.
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What is DIM?
Answer: DIM (or 3,3 diindolylmethane) is the biologically active form of indole-3-carbinol, a naturally occurring plant chemical found in certain types of vegetables. When ingested, the indole-3-carbinol naturally present in cruciferous vegetables can be converted into DIM.
What is the recommended use of Pure Lab’s DIM?
Answer: The recommended use of Pure Lab’s DIM is as an antioxidant, to help support hormone balance in males and females.
What situations might benefit from using Pure Lab’s DIM?
Answer: Situations that may benefit from Pure Lab’s DIM include premenstrual syndrome, breast pain, PCOS, acne, heavy periods and endometriosis in females and prostate concerns or testosterone imbalance and acne in males. Since DIM helps the liver detoxify estrogen, it may be helpful in the clearance of estrogen-mimicking chemicals found in certain plastics, perfumes and preservatives from the bloodstream.
What is the recommended dose of Pure Lab’s DIM?
Answer: The recommended dose of Pure Lab’s DIM is 1 capsule daily, or as directed by a healthcare practitioner.
How much DIM is contained in 1 capsule of Pure Lab’s DIM?
Answer: Each capsule of Pure Lab’s DIM contains 200 mg of DIM.
What’s special about Pure Lab’s DIM?
Answer: Pure Lab’s DIM is packed in an acid-resistant capsule, for protection against the harsh conditions of the upper GI tract. DIM is a delicate compound, that can be damaged by highly acidic environment such as the stomach. When taken on an empty stomach, our acid-resistant capsule protects DIM from stomach acid for 30 minutes. This enables the DIM to reach the small intestine intact, where it is absorbed.
How do I take Pure Lab’s DIM?
Answer: Pure Lab’s DIM should be taken with water, on an empty stomach, 30 minutes before a meal.
What is the source of DIM used in Pure Lab’s DIM capsules?
Answer: The DIM in Pure Lab’s DIM is produced by biosynthesis using indole-3-carbinol, its precursor, which is found in cruciferous vegetables.
Can’t I get DIM by eating cruciferous vegetables?
Answer: Cruciferous vegetables contain the precursor to DIM. They do not contain DIM itself. Food preparation methods and general health status can impact an individuals’ ability to convert indole-3-carbinol from these vegetables into DIM. In addition, DIM carries a much lower risk of GI discomfort, gas and bloating than eating cruciferous vegetables. Pure Lab’s DIM has these advantages over consuming cruciferous vegetables.
What is the benefit of taking DIM over indole-3-carbinol?
Answer: Unlike indole-3-carbinol, DIM is not negatively impacted by medications which reduce stomach acid, like antacids and proton-pump inhibitors. DIM is fully activated and ready to support hormone balance.
Are there any side effects I may notice while taking Pure Lab’s DIM?
Answer: Some individuals may experience a change in urine colour, from yellow to orange or light green. This is a normal and harmless side effect of metabolizing DIM.
Is Pure Lab’s DIM vegan?
Answer: Pure Lab’s DIM contains no animal-derived ingredients. It is vegan.
Is there anyone who shouldn’t use Pure Lab’s DIM?
Answer: Consult a health care practitioner before using Pure Lab’s DIM if you are pregnant or breastfeeding. Females experiencing symptoms of low estrogen, such as joint pain, mood changes and irregular menstruation should also consult with their health care practitioner before using Pure Lab’s DIM.
Is Pure Lab Vitamins a Canadian company?
Answer: Yes, Pure Lab Vitamins is proudly Canadian owned and operated. Our products are made in Canada.
Is Pure Lab’s DIM made in a GMP-certified facility?
Answer: Yes, Pure Lab’s DIM is made in a GMP-certified facility.
Is Pure Lab’s DIM third-party tested?
Answer: Yes, Pure Lab’s DIM is third-party tested. Our raw materials and finished goods are always tested by ISO-certified labs.
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